Alpina Burkard Bovensiepen GmbH has produced the Alpina B7 Bi-Turbo performance variant based on the 750i commencing with the 2011 model year. In North America, the BMW Alpina B7 is officially sold by BMW and have BMW VINs, whereas the Alpina B7 BiTurbo sold in Europe and Japan is officially an Alpina. The Alpina B7's engine is assembled by hand at Alpina's facility in Buchloe, Germany, before being shipped to BMW for installation, and the assembled vehicle is then sent back to Alpina for finishing touches.

Alpina's variant of the N63 twin-turbo 4.4-liter V8 makes 507 PS (373 kW; 500 hp) / 700 N·m (516 lb·ft), while retaining the same fuel economy as the regular N63. This is the first time that BMW M and Alpina are using the same type of forced-induction for their powerplants; Alpina's engine has less horsepower but more torque than the BMW M5 (F10).